Professor David Van Vactor discusses how growth cones read molecular 'signposts,' which help axons find the correct path.
Transcript:
So, the growth cone expresses on its surface a variety of receptors that allow the growth cone to recognize both attractive and repellent cues - stop signs and green lights in the embryonic environment. And these guideposts are there to give the growth cone signals that will define its path. But in order to find the correct path, the growth cone has to respond correctly to those signals and translate the stop and the go signal into forward movement or avoidance.
Synaptic Ras GTPase-activating protein 1 (SynGAP), also known as A0024, is a negative regulator of the Ras-cyclic adenosine monophosphate (cAMP) pathway.
In this section learn that a signaling pathway begins with the arrival of a chemical signal – such as a hormone or growth factor – at the cell surface.
Dihydropyrimidinase-related protein 2 (DPYSL2), also named Collapsin response mediator protein 2 (CRMP2 or A0442), is a ubiquitously expressed cytoplasmic protein.
In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.