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ID 1213

PSD-95 and Learning

Description:
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
Transcript:
PSD95, also known as post-synaptic density 95, is very important in the history of learning research because it binds to a neurotransmitter receptor. If you lack PSD95 then you have great difficulty learning, although the receptor still works. This establishes the fact that proteins associated with neurotransmitter receptors are instrumental in the learning process.
Keywords:
psd95, psd-95, psd, 95, post-synaptic, postsynaptic, density, neurotransmitter, receptor, protein, gene, molecule, learning, memory, seth, grant
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Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
1833. PSD95/A0013
Post-synaptic density 95 protein (PSD95), also known as synapse-associated protein 90 (SAP90) or A0013, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
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Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.
1368. DLG4 Gene
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
1834. SAP102/A0016
Synapse-associated protein 102 (SAP102 or A0016) is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
1829. PSD93/A0014
Post-synaptic density protein 93 (PSD93), also known as channel-associated protein of synapse-110 (Chapsyn-110) or A0014, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
1764. SHANK2/A0081
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) is a member of the Shank gene family known as A0081.
1216. Hebbosome
Professor Seth Grant introduced the word 'hebbosome' to describe the multiprotein complex that converts neural activity patterns into a memory trace.
897. Gene knockout in mice
This method uses homologous recombination to disable a gene of interest to produce a genetic knockout.
1390. Genes for Learning and Memory
An interactive chromosome map of the genes and loci associated with learning and memory.
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