Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
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PSD95, also known as post-synaptic density 95, is very important in the history of learning research because it binds to a neurotransmitter receptor. If you lack PSD95 then you have great difficulty learning, although the receptor still works. This establishes the fact that proteins associated with neurotransmitter receptors are instrumental in the learning process.
Post-synaptic density 95 protein (PSD95), also known as synapse-associated protein 90 (SAP90) or A0013, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
Synapse-associated protein 102 (SAP102 or A0016) is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
Post-synaptic density protein 93 (PSD93), also known as channel-associated protein of synapse-110 (Chapsyn-110) or A0014, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).