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ID 15012

Oswald Avery

Description:
In 1944, Avery and MacLeod, and McCarty purified the transforming principle of Fred Griffith's earlier experiment with pneumocossus bacteria. By a process of elimination, these scientists showed that DNA was the factor that caused genetic transformation. DNA is the molecule of inheritance. (DNAi location: Timeline > pre 1920s)
Keywords:
oswald avery,genetic transformation,fred griffith,process of elimination,transforming principle,macleod,detergent,molecule,inheritance,bacteria,enzymes,dna,scientists
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

16375. Animation 17: A gene is made of DNA.
Oswald Avery explains Fred Griffith's and his own work with Pneumococcus bacteria.
16374. Concept 17: A gene is made of DNA.
Oswald Avery's team proves that DNA, not protein, is the genetic molecule.
15674. Oswald Avery (c.1930)
Oswald Avery, circa 1930.
16392. Biography 17: Maclyn McCarty (1911- 2005)
In 1944, Maclyn McCarty and his colleagues, Colin MacLeod and Oswald Avery published their landmark paper on the transforming ability of DNA.
16391. Biography 17: Oswald Theodore Avery (1877-1955)
In 1944, Oswald Avery and his colleagues, Colin MacLeod and Maclyn McCarty published their landmark paper on the transforming ability of DNA.
16381. Gallery 17: Oswald Avery's letter to his brother, 1943
A page from the May 15, 1943 letter from Oswald Avery to his brother Roy. In the letter Avery speculated on how transformation could happen. Avery never publicly connected genes with DNA and his transformation experiments.
16705. Animation 34: Genes can be moved between species.
Stanley Cohen and Herbert Boyer transform bacteria with a recombinant plasmid, and Doug Hanahan studies induced transformation.
16386. Video 17: Maclyn McCarty, clip 2
Relating how Avery was a successful orator while an undergraduate at Colgate University, and his subsequent disdain for public speaking as a scientist.
16395. Animation18: Bacteria and viruses have DNA too.
Joshua Lederberg worked with bacterial genetics while Alfred Hershey showed that DNA is responsible for the reproduction of new viruses in a cell.
16390. Video 17: Maclyn McCarty, clip 6
How the bacterial transformation experiments provided the first real opportunity to study the chemical nature of the gene.
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