Using DNA microarrays to study cancer, Patrick Brown
Description:
Interviewee: Pat Brown.
Pat Brown talks about using microarrays to discover the differences between cancer cells and healthy cells.
(DNAi Location: Applications > Genes and medicine > genetic profiling > Patrick Brown > Using microarrays to study cancer)
Transcript:
Well we knew that differences in the gene expression program were largely responsible for the differences in the appearance and the behavior of the normal cells in our body, say a brain cell compared to a liver cell. And so it seemed natural that by looking systematically at the gene expression program in cancer cells, we would be able to get a better understanding of why those cells are different from their normal counterpart and why a breast cancer in one woman looks and behaves differently from a breast cancer in another woman.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.