Better cancer therapies by identifying oncogenes, David Botstein
Description:
Interviewee: David Botstein.
David Botstein discusses how identifying the molecular mechanisms of cancer will lead to the development of improved therapies.
(DNAi Location: Applications > Genes and medicine > Genetic profiling > David Botstein
Better therapies)
Transcript:
There are also gene expression patterns that are characteristic of particular kinds of oncogene activities and then if you can identify the oncogene that is characteristically over expressed or poorly expressed in a particular tumor, you can then make drugs against it and Gleevec™ and Iressa™ are drugs of that kind.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Professor Bert Vogelstein, explains that cancer is in essence a genetic disease. It is caused by mutations of genes and there are three types of genes, that contribute to cancer.