Gilbert's approach to synthesizing insulin, David Goeddel
Description:
Interviewee: David Goeddel.
David Goeddel talks about how another group was trying to make insulin.
(DNAi Location: Manipulation > Production > Players > David Goeddel > The other strategy)
Transcript:
So the approach at least as far as we were aware, that the Gilbert group was following, was to isolate a natural gene or a copy of a natural gene for human insulin, and then they of course would have the cloning of it in the expression. But the starting point was very different, using natural DNA as composed to synthetic DNA... compared to synthetic DNA.
David Goeddel was one of the first scientists Herb Boyer hired for the insulin project. Here, David Goeddel talks about Genentech's general strategy for synthesizing insulin.
In the late 1970s, there was a moratorium on recombinant DNA work. Gilbert had to go to England's Porton Down facility to try and isolate human insulin.