The early stages of the hunt for BRCA1, Mary-Claire King
Interviewee: Mary-Claire King.
Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
(DNAi Location: Applications > Genes and medicine > Gene hunting > Mary-Claire King >
What she was looking for)
So what we were looking for was some fragment of DNA flagging some chromosome somewhere in the genome, that was shared by all of the cancer cases in the family, all of the women with cancer, and was not held by branches of the family where there had been few women with cancer.
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By 1990, King had found a "landmark" that helped her fix the gene's position on a chromosome. This DNA marker was on chromosome 17, and was linked to breast cancer in a subset of the families she studied. She teamed up with Francis Collins in a race to f