Interviewee: Jim Kent. Banding appears in dyed chromosomes. Jim Kent talks about banding appears in dyed chromosomes.

If you stain a human chromosome just right you'll see a banding pattern. And people do this all the time because it turns out that a lot of times in cancer cells will have the wrong number of chromosomes, or they'll have chromosomes that are fused and joined. There's quite a bit of medical knowledge about these bands. So, this is maybe the highest level view you can see. And it just turns out that the dark areas tend to be not so actively transcribed. They're sort of all dense and kind of curled up inside themselves and packed away tightly so that they're not taking up so much space in the cell. And then the others will be more open and be actively used.

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