Website Search
ID 15410

Chromosome 15: Prader-Willi's disease, or Angelman's syndrome, Matt Ridley

Description:
Interviewee: Matt Ridley. Genes on chromosome 15 show an effect called "imprinting." The effect of mutations in these genes varies depending on whether they are inherited from the mother or the father, which appears to play different roles in human development. Genes from the father govern the production of the placenta, and genes from the mother are responsible for organizing cells in the embryo, especially the head and brain. (DNAi Location: Genome > Tour > Genome spots > Chromosome 15: Prader-Willi/Angelman syndrome > A chromosome 15 story)
Transcript:
You get two copies of each gene, one from your father and one from your mother. It shouldn't matter which comes from which, and in most cases it doesn't. But in a very few genes, there seems to be something called maternal or paternal imprinting, and that means that the gene behaves differently, according to whether it comes from the father or the mother." +" This causes some very strange diseases, which manifest themselves according to whether you got them through the paternal or maternal line. Here on chromosome 15, there is one such pair of diseases, Prader-Willi's disease, or Angelman's syndrome. These imprinted genes have a role in building the brain. It seems as if most of the construction of the brain is done by genes inherited from your mother. Nobody quite knows why.
Keywords:
angelman syndrome,chromosome 15,matt ridley,development genes,strange diseases,prader willi,maternal line,dnai,gene name,interviewee,placenta,mutations,embryo,cells,brain
Downloads:
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15965. What is Prader-Willi/Angelman?
Genes on chromosome 15 show an effect called "imprinting." The effect of mutations in these genes varies depending on whether they are inherited from the mother or the father, which appears to play different roles in human development. Genes from the fath
15399. Chromosome 4: Huntington's Disease, Matt Ridley
Matt Ridley talks about chromosome 4, Huntington's Disease.
15413. Chromosome 18: BCL2 oncogene, Matt Ridley
Matt Ridley talks about chromosome 18, BCL2 oncogene.
15416. Chromosome 21: trisomy and Down Syndrome, Matt Ridley
Matt Ridley talks about chromosome 21, trisomy and Down Syndrome.
15420. Y Chromosome: SRY gene responsible for the masculinization process, Matt Ridley
Matt Ridley talks about Y Chromosome, SRY gene responsible for the masculinization process.
15415. Chromosome 20: gene for adenosine deaminase, Matt Ridley
Matt Ridley talks about chromosome 20, gene for adenosine deaminase.
15408. Chromosome 13: BRCA2 gene for breast cancer susceptibility, Matt Ridley
Matt Ridley talks about chromosome 13, BRCA2 gene for breast cancer susceptibility.
15407. Chromosome 12: HOX genes of development, Matt Ridley
Matt Ridley talks about chromosome 12, HOX genes of development.
15397. Chromosome 2: fusion of 2 small chromosomes, Matt Ridley
Matt Ridley talks about chromosome 2, fusion of 2 small chromosomes.
881. Hotspot for Autism Genes
Several lines of research are converging to show how opposing genetic pathways can lead to autism.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving