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Making GeneChips™ at Affymetrix

Description:
Affymetrix, the makers of GeneChip arrays. GeneChips help scientists identify genetic variations associated with diseases such as cancer. This information can be used to develop better methods for diagnosis and treatment. What you see here is the GeneChip production facility. GeneChips consist of hundreds of thousands of different DNA probes printed on quartz wafers. To assemble these probes on wafers, technicians alternate between a special printing process called photolithography and DNA synthesis. Here, photolithography is done on the left, and DNA synthesis is done on the right.
Transcript:
Genechip image 1<br><br> Welcome to Affymetrix, the makers of GeneChip arrays! GeneChips help scientists identify genetic variations associated with diseases such as cancer. This information can be used to develop better methods for diagnosis and treatment. What you see here is the GeneChip production facility. GeneChips consist of hundreds of thousands of different DNA probes printed on quartz wafers. To assemble these probes on wafers, technicians alternate between a special printing process called photolithography and DNA synthesis. Here, photolithography is done on the left, and DNA synthesis is done on the right.
Keywords:
quartz wafers,dna probes,dna synthesis,genetic variations,photolithography,printing process,arrays,hundreds of thousands,diagnosis,diseases,scientists,cancer
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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15662. Making GeneChips™ at Affymetrix
Here you can see a technician shuttling a quartz wafer (containing 50-400 GeneChips™) between alternating photolithography and DNA synthesis steps.
15665. Making GeneChips™ at Affymetrix
A technician loads a quartz wafer into the DNA synthesizer, where nucleotides will be added to selected sequences to build probes.
15666. Making GeneChips® at Affymetrix
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