Website Search
ID 15704
Gene markers on chromosomes
Description:
By 1990, King had found a "landmark" that helped her fix the gene's position on a chromosome. This DNA marker was on chromosome 17, and was linked to breast cancer in a subset of the families she studied. She teamed up with Francis Collins in a race to find and clone the gene she named BRCA1.
Keywords:
dna marker,gene markers,breast cancer,chromosomes,chromosome,marker,subset,landmark
This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.Related content:
- 15118. What to look for in the hunt for BRCA1, Mary-Claire King
- Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
- SOURCE: DNAi
- 15115. Integrating information using DNA markers, Kenneth Kidd
- Geneticist Kenneth Kidd explains his study of human DNA variation in nuclear chromosomes.
- SOURCE: DNAi
- 15177. Seeing who has the marker, Barbara Weber
- Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
- SOURCE: DNAi
- 15989. Marker Animation
- Watch the animation to learn more about why genetic markers offer important clues in the hunt for genes.
- SOURCE: DNAi
- 15092. Studying the Y chromosome to understand population origins and migration, Michael Hammer
- Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
- SOURCE: DNAi
- 15243. The hunt for BRCA1, Mark Skolnick
- Mark Skolnick talks about the hunt for BRCA1.
- SOURCE: DNAi
- 1072. Identifying Genes - Polymorphic Markers
- Professor Jonathan Finch describes one technique for identifying genes in rodents.
- SOURCE: G2C
- 15125. The early stages of the hunt for BRCA1, Mary-Claire King
- Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
- SOURCE: DNAi
- 15080. Was she at increased risk?, Denise
- Denise talks about learning about DNA, and deciding if she wanted to know if she was at increased risk for breast cancer.
- SOURCE: DNAi
- 15128. Importance of genetic maps, Mary-Claire King
- Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.
- SOURCE: DNAi
