Mark Skolnick is a geneticist who was involved in early genetic linkage studies involving Mormons. In 1990, he formed a company called Myriad Genetics to use the power of the Mormon family history and pedigrees to help map and clone genes. Myriad's first target was a breast cancer gene (BRCA1). In 1994, a group from Myriad and their collaborators announced that they located a strong candidate for BRCA1. Their patent on this gene was granted in 1997. Although they were not the first to find the second breast cancer gene (BRCA2), Myriad was the first to isolate it. They patented BRCA2 in 2001.
(DNAi location: Applications > Genes and Medicine > Gene hunting > Mark Skolnick)
Keywords:
genetic linkage studies,mormon family history,breast cancer gene,myriad genetics inc,clone genes,breast cancer,skolnick,brca1,location applications,target,geneticist,pedigrees,mormons,collaborators,patent,hunting,medicine
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.