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ID 15979

A mitochondrial DNA sequence

Description:
The DNA found in mitochondria, the energy-producing organelles of cells, is often analyzed to trace evolutionary pathways. Mitochondrial DNA (mtDNA) has a high "substitution" or mutation rate, compared with other sites in our genome. mtDNA is transmitted only from mother to child, and can be inherited intact over thousands of generations. Mutations in the mtDNA sequence can be used to reconstruct the maternal lineage of populations.
Keywords:
mtdna sequence,organelles of cells,maternal lineage,mutation rate,mitochondrial dna,dna sequence,mutations,pathways,populations,generations
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15978. Mitochondrial DNA: a closer look
DNA found in the mitochondrion of a cell differs in structure and is separate from the DNA found in the cell nucleus. Mitochondrial DNA, or mtDNA, exists as a circular loop of double-stranded DNA rather than the linear form found in nuclear DNA. However,
15977. Maternal inheritance
Unlike nuclear DNA, mtDNA is  inherited solely from the mother. (Mitochondria are predominantly from the mother’s egg and not from the father’s sperm.) Therefore, mtDNA sequences or orders of nucleotides generally remain constant over many generation
15418. Mitochondrial DNA, Matt Ridley
Matt Ridley talks about Mitochondrial DNA.
15178. Mitochondrial DNA and the molecular clock, Douglas Wallace
Geneticist Douglas Wallace explains a method of mapping a population's history using the mutations accumulated by its members.
15976. Neandertal and human (mtDNA)
When comparing Neandertal and human mtDNA, researchers found that the differences between the sequences put Neandertals outside the range of variation of modern humans.
15975. Human and mtDNA variation
When comparing Neandertal and human mtDNA, researchers found that the differences between the sequences put Neandertals outside the range of variation of modern humans.
16655. Problem 30: Higher cells incorporate an ancient chromosome.
Trace mitochondria through Queen Victoria's decendents and solve the mystery of the Romanovs.
15980. Accumulating mutations
Mutations are the grist of evolution, and have accumulated in our DNA over time. When populations separate, each group accumulates their own unique set of DNA mutations.
16088. mtDNA tree all humans; Macaulay
Mitochondrial genome sequences humans populations modern MRCA most recent common ancestor ancestry relationships phylogenetic trees mtDNA Macaulay.
15611. mtDNA / Y chromosome pedigree, animated image
A pedigree illustrating maternal inheritance of mtDNA and paternal inheritance of the Y chromosome.
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