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ID 15994
The chronic myeloid leukemia (CML) mutation
Description:
View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.
Keywords:
chronic myeloid leukemia,philadelphia chromosome,abnormal chromosome,cml,leukemia,mutation,animation
This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.Related content:
- 15706. Philadelphia chromosome
- A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.
- SOURCE: DNAi
- 1013. Diagnosis, Targeted therapies: Targeting activators, Sawyer 1
- Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.
- SOURCE: IC
- 15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration
- View the animation to find out how the drug Gleevec⢠inhibits the molecular cause of chronic myeloid leukemia.
- SOURCE: DNAi
- 15712. Bud and Yvonne
- Bud and Yvonne are delighted by Bud's recovery thanks to Gleevec
- SOURCE: DNAi
- 15714. Brian Druker
- Brian Druker is a professor at Oregon Health Sciences University.
- SOURCE: DNAi
- 15041. Getting the diagnosis of chronic myeloid leukemia, Bud
- Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.
- SOURCE: DNAi
- 1012. Diagnosis, Targeted therapies: Targeting activators
- In this section learn that tyrosine kinases are a family of activator proteins that trigger the cell signaling process leading to cell growth and division.
- SOURCE: IC
- 15055. Using DNA science to control CML, Brian Druker
- Brian Druker talks about how the drug he designed targets the molecular cause of CML.
- SOURCE: DNAi
- 1014. Diagnosis, Targeted therapies: Targeting activators, Sawyer 2
- Professor Charles Sawyer explains that Gleevec is a pill taken once a day and works remarkably well in all phases of CML.
- SOURCE: IC
- 1015. Diagnosis, Targeted therapies: Targeting activators, Sawyer 3
- Professor Charles Sawyer explains that the CML clone makes mistakes in DNA replication and generates a diverse repertoire of mutations.
- SOURCE: IC
