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ID 15994

The chronic myeloid leukemia (CML) mutation

Description:
View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.
Keywords:
chronic myeloid leukemia,philadelphia chromosome,abnormal chromosome,cml,leukemia,mutation,animation
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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15706. Philadelphia chromosome
A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.
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Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.
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Professor Charles Sawyer explains that Gleevec is a pill taken once a day and works remarkably well in all phases of CML.
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Professor Charles Sawyer explains that the CML clone makes mistakes in DNA replication and generates a diverse repertoire of mutations.
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