Video 21: Paul Zamecnik, clip 5

Dr. Zamecnik is Professor Emeritus at Harvard University, and is a member of the Board of Directors of Hybridon, Inc., a biotechnology company he helped found.

hybridon inc, protein synthesis, biotechnology company, harvard university

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16485. Video 21: Paul Zamecnik, clip 2

The background and motivation for developing a cell-free protein synthesis system, and how the focus soon changed to finding out "what the machinery was like."

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  • Source: DNAFTB

16484. Video 21: Paul Zamecnik, clip 1

Describing an early experience that led to interest in studying protein synthesis.

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16487. Video 21: Paul Zamecnik, clip 4

The role of "pseudo-serendipity" in making discoveries: finding the missing RNA components in the protein synthesis system.

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16486. Video 21: Paul Zamecnik, clip 3

Describing the cell fractionation experiments to isolate the components needed for protein synthesis.

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16489. Biography 21: Paul Charles Zamecnik (1913-2009)

Paul Zamecnik developed a cell-free extract that he and Mahlon Hoagland used to study protein synthesis. They identified tRNA as the adaptor predicted by Francis Crick in his Central Dogma

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16757. Biography 36: Stephen P. A. Fodor (1953- )

Steve Fodor changed the way genomes can be screened with GeneChips®.

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16694. Video 33: Walter Gilbert, clip 1

Before Jacob and Monod, people thought the amount of protein in a cell was constant and proteins turned themselves off.

  • ID: 16694
  • Source: DNAFTB

16695. Video 33: Walter Gilbert, clip 2

Jacob and Monod discovered that genes control the amount of protein in a cell.

  • ID: 16695
  • Source: DNAFTB

16696. Video 33: Walter Gilbert, clip 3

Where did the idea of negative control come from?

  • ID: 16696
  • Source: DNAFTB

16698. Video 33: Walter Gilbert, clip 5

Jacob and Monod never identified the inhibitor, but Gilbert found it.

  • ID: 16698
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