Concept 38: Development balances cell growth and death.
Normal development requires growth as well as apoptosis, or programmed cell death.
In a biological sense, growth results from the reproduction of new cells from pre-existing ones, by the process of cell division (mitosis). Once a tissue or organ reaches an appropriate size, mitosis slows and cells enter a resting phase. This cell cycle of growth and rest is controlled by "checkpoint" molecules first characterized in the 1980s and 1990s in yeast, and then in other eukaryotes.
Remarkably, normal development requires that some healthy cells be eliminated, killed, by a process called "apoptosis." Initial clues about the nature of apoptosis came from detailed studies of the roundworm Caenorhabditis elegans, in which development of each of the 959 cells in the adult can be traced from the fertilized egg.
Analysis of cell "fates" showed that specific cells are programmed to die at specific times during embryonic development. Disruptions in the program lead to an overabundance of cells — a hallmark of cancer.