The mosquito, Anopheles gambiae, has become an important model organism for the study of insect – parasite interactions and innate immune responses.
Anopheles gambiae has become an important model organism for the study of insect – parasite interactions and innate immune responses to a protozoan parasite. When investigating the molecular responses of vertebrate epithelial cells to parasite invasion, the mosquito is an excellent model organism. Studies of innate immunity in insects and vertebrates are merging as new information confirms the extent of evolutionary conservation in the signaling pathways mediating immune responses.
A human is a complicated organism, and it is considered unethical to do many kinds of experiments on human subjects. For these reasons, biologists often use simpler “model” organisms that are easy to keep and manipulate in the laboratory.
Each model organism has its own advantages and disadvantages. Choosing an appropriate model depends on the question being asked. Many laboratories find it useful to perform parallel experiments in two or more model systems to understand different aspects