Yeast was the first eukaryote organism to have its entire genome sequenced. It has remained at the forefront of genetics research because it is quick and easy to grow.
Yeast was the first eukaryote organism to have its entire genome sequenced. It has remained at the forefront of genetics research because it is quick and easy to grow with an 80 minute generation time. Unlike many other microorganisms, strains of S. cerevisiae have both a stable haploid and diploid state. This makes it easy to isolate recessive mutations. The cell cycle in yeast is very similar to the cell cycle in humans and is regulated by homologous proteins. The discovery in yeast of two close homologs of the mammalian ras proto-oncogene is evidence of conservation from the simple yeast organism to the complex human organism. By examining the yeast genome sequence, it is possible to estimate how many yeast genes have significant mammalian homologs.
A human is a complicated organism, and it is considered unethical to do many kinds of experiments on human subjects. For these reasons, biologists often use simpler “model” organisms that are easy to keep and manipulate in the laboratory.
Nobel Prize week kicked-off today with the announcement of the Prize in Physiology or Medicine. Elizabeth Blackburn, Carol Greider, and Jack Szostak will share the award for discovering telomeres and telomerase. Dr. Bruce Stillman, President of Cold Sprin