Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years.
Transcript:
There are several different types. Early-onset familial Alzheimer’s disease is typically caused by genetic mutations that we can follow through families. These genetic mutations, for the most part, increase the production of amyloid beta in the brain. These patients, typically by 50 or 60 have reasonably advanced Alzheimer’s disease.
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,
Professor Donna Wilcock dscusses the cholinergic hypothesis of Alzheimer's disease, which focuses on cholinergic neurons. The hypothesis has not been supported.
Doctor Thomas Insel discusses recent findings of structural changes in the brains of teenagers may be warning signs for the potential onset of Alzheimer's disease.
Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.