In 2001, the DNALC initiated a formal program to assist institutions and governments that wish to quickly and efficiently implement a "hands-on" science center devoted to modern biology education. Under the licensing plan, institutions have transparent access to DNALC teaching methods, Internet technology, and intellectual property ("know-how") developed at a cost of more than $25 million.
Within a year of signing a licensing agreement, two facilities based on the DNALC model came online in the Republic of Singapore - one to serve teachers and the other to serve students. The DNA Centre at the National Institute of Education (NIE), which features two teaching labs, a bioinformatics lab, and small exhibit space, provided workshops for 625 teachers in 2003. The DNA Learning Lab at the Singapore Science Centre - with dual "Watson" and "Crick" teaching labs surrounded by a "DNA Trail" exhibit - conducted experiments with 6,356 visitors and held orientations for 1,200 educators. Complete mirrors of the DNALC Internet sites were also installed at NIE and the Singapore Bioinformatics Institute.
In 2003, Clemson University joined the ranks of current licensees. Clemson initiated the South Carolina DNA Learning Center with an initial grant of $500,000, with the intent to focus on agricultural genetics.