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ID 1007

Diagnosis, Pathology: Demarzo clip 2

Description:
Professor Angelo De Marzo explains that special dyes are utilized to stain cells and when we look at the stained cells under the microscope we look for changes in the architecture of cells.
Transcript:
Angelo De Marzo M.D., Ph.D. is a pathologist at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. His current research focuses on the inflammatory response and its link to prostate cancer. The research may lead to new diagnostic tests for early detection. “Most people don't realize all human tissue is actually transparent until we apply special dyes. So we typically use hemotoxilyn – a very beautiful dye – hemotoxilyn is actually from the bark of a tree. We've been using it for almost 100 years in this country. When we look at that under the microscope we look for a couple things. We usually use the architecture of the cells, how they are arranged together, and also the individual cells themselves. And so a cancer cell, the nucleus of the cell gets very big and it absorbs more dye. It's called hyperchromasia. The nucleus gets abnormal in shape and so in general, pathologists can tell the biological behavior and can guess it by changes in cell shape and structure.”
Keywords:
sidney kimmel comprehensive cancer center, sidney kimmel comprehensive cancer center at johns hopkins, diagnosis pathology, comprehensive cancer center, cell shape, biological behavior, cancer cell, sidney kimmel comprehensive, human tissue, inflammatory response, prostate cancer, diagnostic tests, pathologist, dyes, nucleus, microscope, cells
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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