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Diagnosis, Pathology: Demarzo clip 3

Description:
Professor Angelo De Marzo explains that if you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly.
Transcript:
Angelo De Marzo M.D., Ph.D. is a pathologist at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. His current research focuses on the inflammatory response and its link to prostate cancer. The research may lead to new diagnostic tests for early detection. “If you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly. They’re not talking, they’re not throwing spitballs. They are behaving very nicely and listening to the teacher. A cancer cell would be a population of students that are running around throwing paper airplanes, they are not dressed properly, one might be sitting on another one’s lap. The cells literally don’t behave in terms of their structure and they might invade their next door neighbor’s space. Some of them are too big and some of them are too small so you get what is called polymorphism. So normal, in this analogy, all the kids in the class would all be the same height and weight. In the cancer cell you have a 300 pounder, next to a one pounder, next to you know all different types of people. So that they really socially don’t behave properly as a cell and that’s really what we are looking for.”
Keywords:
sidney kimmel comprehensive cancer center, sidney kimmel comprehensive cancer center at johns hopkins, diagnosis pathology, comprehensive cancer center, shirts and ties, cancer cell, inflammatory response, prostate cancer, height and weight, pounder, diagnostic tests, pathologist, analogy, neighbor, cells, population
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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