Professor David Van Vactor discusses what happens during neurodevelopment when an axon reaches its final destination.
So, when a growth cone reaches its final destination, the neuron faces a need to change from an exploratory mode, to find its partner, to a new mode in which it will create functional active synaptic connections. In some cases the growth cone itself will transform from a motile exploratory apparatus into a stable connection, a synaptic partner.
growth, cones, axon, guidance, neurodevelopment, van vactor,
L1 cell adhesion molecule (L1CAM), also known as neural cell adhesion molecule 1 or A0290, is a member of a subgroup of integral membrane proteins that belong to the immunoglobulin superfamily cell adhesion molecules (CAM).