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Professor Seth Grant provides a definition of proteomics - the study of the properties of a large numbers of proteins.
Proteomics can be defined as the study or the approach to studying large numbers of proteins or the properties of many proteins. Previously, protein biochemistry focused usually on just one protein and its properties, but new methodologies such as mass spectrometry can be used to study hundreds of thousands of proteins all in one shot.
proteomics, protein, mass, spectrometry, seth, grant
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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1303. Mass Spectrometry
Doctor Thomas Nuhse explains that mass spectrometry is a technique for measuring the mass of molecules, which therefore allows researchers to identify molecules.
1218. Small World Protein Networks
Professor Seth Grant explains that a small world protein network is a network where all proteins are closely connected.
1213. PSD-95 and Learning
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
1207. Genes to Cognition Continuum
Professor Seth Grant outlines one way in which the Genes to Cognition Research Programme uses model organisms to study learning and memory in humans.
1212. NMDA Receptors and Learning (1)
Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
1215. PSD-95 Mutations
In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
1220. Cocaine and Memory Loss
Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.
1217. Long- and Short-term Memory Differences (2)
Professor Seth Grant explains that long-term memories are created when the synapse sends a signal to the nucleus to activate certain genes.
1216. Hebbosome
Professor Seth Grant introduced the word 'hebbosome' to describe the multiprotein complex that converts neural activity patterns into a memory trace.
1206. Genes to Cognition Research
Professor Seth Grant explains that the Genes to Cognition research program is investigating the network of proteins that are important to learning.
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