Website Search
ID 1392

Biochemistry of Depression

Description:
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
Transcript:
There are three major neurotransmitters associated with depression. The one we hear most about these days is serotonin, there is dopamine, and there is norepinephrine. I would like to say a little bit about dopamine because dopamine deficiency is found in the synapses of people who are drug-dependent or engage in compulsive behavior - compulsive gambling, compulsive spending, compulsive shopping. The major area of the brain that seems to be affected by substance abuse and compulsive behaviors is the nucleus accumbens.
Keywords:
depression, dopamine, serotonin, and norepinephrine, nucleus accumbens, neurochemical, biochemical, neurotransmitter, chemical, chemistry, jon, lieberman,
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1402. Serotonin Receptors and SSRIs
Doctor Jon Lieberman discusses the propsed mechanism of Selective Serotonin Reuptake Inhibitors (SSRIs), a controversial treatment for depression.
1165. Dopamine and Schizophrenia
Professor Daniel Weinberger explains that dopamine is the major focus of biochemical research into schizophrenia.
814. Dopamine Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
2080. Biochemistry of depression
Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.
2124. Treatments for depression and recovery
Professor Helen Mayberg describes treatments for depression: medication, therapy, or a combination of the two. About 40% of patients recover entirely, while about 10% do not respond.
1397. Depression - Lifestyle
Doctor Jon Lieberman describes some of the life-events that may have been a factor in his first major depressive episode at 52 years of age.
1145. Drug Addiction - Chemistry and the Brain
Professor Trevor Robbins explains that drug addiction involves chemical and neural processes with dopamine and the nucleus accumbens particularly important.
2225. Depression
An overview of depression-related content on Genes to Cognition Online.
2356. Biochemistry of Bipolar Disorder
Doctor Ellen Leibenluft discusses some of the biochemicals that have been associated with bipolar disorder, including dopamine, serotonin, and glutamate.
2164. Biochemistry of ADHD - serotonin
Professor Philip Shaw discusses the relationship between serotonin and ADHD.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving