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ID 1450

Presenilin 2 Gene

Description:
Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons.
Transcript:
Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons. Presenilin 1 and Presenilin 2 determine gamma-secretase activity, which is responsible for cleaving the amyloid precursor protein (APP). In turn, APP cleavage can produce amyloid-beta, which is the primary component of plaques in the brains of Alzheimer’s disease patients. It follows, that interactions between presenilins and APP are critical to the cause/prevention of Alzheimer’s disease, and presenilins have been consistently shown to associate with the disorder (see, for example a review by Selkoe and Wolfe, 2007).
Keywords:
alzheimer's, genes, presenilin, ps2, psen2, cleavage, plaques, proteins, gamma secretase, cell membrane
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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