Website Search
ID 1451

Apolipoprotein (APOE) Gene

Individuals with two copies of APOE4, have a dramatically increased risk of developing Alzheimer’s disease.
Apolipoprotein (APOE) is a plasma glycoprotein that contains 299 amino acids. APOE transports vitamins, lipoproteins and cholesterol into the lymph system and blood. It is mainly expressed in the liver, but is found in other tissues, including the brain. There are three major isoforms (versions) of APOE – APOE2, APOE3, and APOE4. The APOE4 isoform is particularly associated with Alzheimer’s disease. In individuals with two copies of APOE4, the risk of developing Alzheimer’s disease increases from 20% to 90% and the average age of onset decreases from 84 to 68 years. APOE4 binds to or retains amyloid-beta, which is the primary component of plaques in Alzheimer’s disease.
alzheimer's, genes, apolipoprotein, apoe, apoe4, isoform, lipoproteins, glycoprotein, plaques, amyloid, beta
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1447. Alzheimer's Disease Candidate Genes
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
2189. Late-onset Alzheimer's disease
Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance and/or production of the amyloid beta protein.
2138. ApoE4, a-beta, and Alzheimer's disease susceptibility
Professor Dennis Selkoe discusses the degree to which the ApoE4 gene is associated with early onset Alzheimer's disease.
2190. Late-onset genes for Alzheimer's disease
Professor Donna Wilcock discusses the late-onset gene for Alzheimer's disease, ApoE4, which increases the risk of developing the disease.
2033. Amyloid precursor protein and Alzheimer's disease
Professor Kenneth Kosik describes the relationship between the amyloid precursor protein (APP) and Alzheimer’s disease. APP mutations are linked to early-onset Alzheimer’s disease.
2135. APP - amyloid clearance and production
Professor Dennis Selkoe compares the amyloid precursor (or parent) protein to a Bic pen. The clasp part seems to be the bad guy, and is part of a network involving presenilin and ApoE4.
794. Background to Alzheimer's Disease
Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,
1742. Serpina3/A0091
Serpina3n (serine or cysteine peptidase inhibitor, clade A, member 3N), also known as A0091, is a serine protease inhibitor composed of a singular glycopeptide chain.
1448. APP Gene
Amyloid precursor protein (APP) is expressed in the synapses of neurons and is thought to be responsible for forming and repairing synapses.
2172. Amyloid plaques
Professor Donna Wilcock describes amyloid plaques as clumps of protein in the brain that are one of the three hallmarks of Alzheimer's disease.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving