Website Search
ID 1466

TPH2 Gene

Description:
Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists.
Transcript:
Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme involved in the synthesis of serotonin (rate-limiting enzymes control the rate of activity in biochemical reactions). Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists. TPH2 has attracted attention as a component of the serotonin hypothesis of depression. It is expressed primarily in brain tissue. A study by Cichon and colleagues (2008) identified a rare single nucleotide polymorphism in the TPH2 gene that resulted in a proline-serine substitution at position 206 (P206S), which significantly correlated with bipolar disorder. Zhang and colleagues (2005) found that a rare TPH2 mutation was significantly more common in a group of individuals with depression. Excitement at this discovery, however, has been tempered by a failure to replicate the finding in a number of follow-up studies.
Keywords:
depression, candidate, gene, Tryptophan hydroxylase 2, TPH2,
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1464. Candidate Genes for Depression
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
1484. Bipolar Disorder Candidate Genes
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
2223. Bipolar disorder
An overview of bipolar disorder-related content on Genes to Cognition Online.
1467. HTR2A Gene
Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
1468. FKBP5 Gene
908. Autism Candidate Genes
Use this chromosome map to explore genes associated with autism.
1465. BDNF Gene
Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.
912. EN2 Gene
Engrailed 2 (EN2) is a gene associated with autism.
2225. Depression
An overview of depression-related content on Genes to Cognition Online.
916. GABRB3 Gene
GABA is the main inhibitory neurotransmitter in the adult brain. GABRA3 is a candidate gene for autism.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving