Website Search
ID 15247

Onto BRCA2, Mark Skolnick

Interviewee: Mark Skolnick. Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2. (DNAi Location: Applications > Genes and medicine > Gene hunting > The finish line > Onto BRCA2)
Well just after we found BRCA1 we were then able to separate the whole set of families we had into those that were linked to BRCA1 and those that showed no linkage. So one member of our team, David Goldgar, teamed up with another player who hadn't been much of a player in the BRCA1 race, Mike Stratten, in an attempt to actually look at linkage information for those unlinked families, for the families that were not likely to be BRCA1 gene-carriers, and to look for the next gene, BRCA2. And why did we do it? We did it because it was the next logical step, your families are now purified, in that you have a clean set of just BRCA2 families. If we're going to offer diagnostic we want to offer a complete diagnostic, that is for both genes, not just one gene, so it was the logical next step for us.
brca1 brca2,cancer diagnosis,cancer cancer,breast cancer,location applications,skolnick,interviewee,finish line,logical step,linkage,genes,discovery,medicine
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15124. Better treatment for breast cancer, Mary-Claire King
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
15718. Mark Skolnick
Mark Skolnick is Chief Scientific Officer at Myriad Genetics, Inc.
15126. Using pedigress in the hunt for BRCA1, Mary-Claire King
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
15703. BRCA1 cloned
A team from Myriad was the first to find and clone BRCA 1.
15121. Little known in the 1970s about the causes of cancer, Mary-Claire King
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
15123. Testing for mutations in BRCA1, Mary-Claire King
Mary-Claire King talks about testing for breast cancer.
15246. Winning the race to find BRCA1, Mark Skolnick
Mark Skolnick discusses how luck was a major element that helped his team win the race to find and clone BRCA1.
15702. BRCA1 and BRCA2 genes
Tests are available to detect certain mutations in the BRCA1 and BRCA2 genes.
15939. What is breast cancer?
BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer
15938. What is breast cancer?
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving