Website Search
ID 15270

Deciding on studying the lac operon, François Jacob

Description:
Interviewee: François Jacob. François Jacob explains why Jacques Monod chose to work with the lactose system. (DNAi Location: Code > Controlling the code > Players > François Jacob and Jacques Monod > Why the lactose system?)
Transcript:
It was by technical reason. Monod started on two systems, one was the lactose and the other was a maltose system, because a maltose was the same, that is, when you put the bacteria into maltose as a carbon source, it makes a series of protein which it makes only in the presence of maltose, not in the absence of maltose. But the enzyme for the lactose were much simpler to assay than the maltose one, so then he chose, he, he chose the lactose system to work in more details.
Keywords:
lac operon,jacques monod,glucose galactose,franis,carbon source,dnai,location code,technical reason,interviewee,bacteria,jacob,maltose,protein,presence,absence
Downloads:
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15269. The discovery of the lac operon, François Jacob
François Jacob talks about how enzyme production was viewed at the time they were beginning their experiments.
15271. Discovering the lac operon, François Jacob
François Jacob talks about bacterial mutants that could not metabolize lactose. Using these mutants, Jacob and Monod figured out how protein production is controlled.
15272. The molecular biology of the lac operon, Fraois Jacob
François Jacob talks about the relationship between DNA, ribosomes, and protein production.
16688. Animation 33: Genes can be turned on and off.
Jacques Monod and Francois Jacob work with how bacteria breaks large sugars into smaller pieces.
15268. Designing bacteria, François Jacob
François Jacob talks about designing bacteria.
15884. The lac operon
Francois Jacob and Jacques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein productio
15276. Genes control the structure of proteins, François Jacob
François Jacob talks about Genes control the structure of proteins
15273. Who named messenger RNA?, François Jacob
François Jacob talks about how he and Jacques Monod named messenger RNA.
15886. Lac operon problem
The first model for the control of protein production was the lac operon. This system of feedback and negative regulation is used by bacteria, however, the general principles also apply to higher organisms. Another method of protein regulation involves
15274. The production of messenger RNA, François Jacob
François Jacob, Sydney Brenner and Matt Meselson worked on the role of mRNA. An on/off switch involving mRNA seemed a logical control point for protein production.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving