Interviewee: James Watson. James Watson defines the Central Dogma. (DNAi Location: Code > Copying the code > players > James Watson and Francis Crick > The Central Dogma)

Of course Francis and I talked about protein synthesis and there was evidence that protein synthesis occurred in the cytoplasm of cells, not in the nucleus, so protein synthesis occurred removed from the chromosomes, or seemingly removed from the chromosomes, it occurred on particles which contained RNA. So I thought there must be some system by which the information is transferred from DNA to RNA and then RNA provides the information, is the direct template for protein synthesis. I wrote that on a little piece of paper and taped it above my desk.

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