Chromosome 11 Flyover (Part 4): TRIM genes and olfactory receptors, 3D animation
Just as we chart the world around us, we can map human chromosomes. The features of chromosomes can include protein-coding genes, ancient molecular parasites known as transposons, or stretches of repeat sequences.
In this section, take a guided tour of less than 1% of your genetic material to see new and unusual views of your chromosomal landscape.
(DNAi location: Genome > Tour > Flyover > TRIM and olfactory receptor clusters)
Next follows a cluster of four genes in the tripartite motif (TRIM) family. TRIM proteins contain three motifs, or structures, through which they bind to DNA to regulate gene activity. Averaging about 21,000 nucleotides and having about eight coding exons, the TRIM genes come very close to the average size of human genes. Different proteins can be produced by a single TRIM gene, by making different combinations of coding exons. TRIM 34 and 22 help mediate the antiviral activity of interferon and offer insight into the fight against HIV. Our tour ends with another cluster of nine olfactory receptor genes (LOC). Chromosome 11 contains about 40% the estimated 1,000 genes for olfactory receptors in the human genome. There is such a concentration of receptor genes at the tip of Chromosome 11 that this whole region could be called an olfactory supercluster, in which the beta globin, ubiquilin, and TRIM clusters are embedded.