Mice used as model organisms

Gene targeting techniques are used by scientists to simulate human genetic disorders in model organisms. Many scientists believe that gene targeting will lead the way to new methods for correcting genetic defects. Pioneered by Mario Capecchi, gene targeting is a process in which scientists use embryonic stem (ES) cells to simulate genetic disorders in mice, study their development, and test new therapies. Many believe that gene targeting will lead the way to new methods for directly correcting genetic defects.

human genetic disorders,mario capecchi,model organisms,genetic defects,genetic disorders,embryonic stem,mice,scientists,cells

  • ID: 15707
  • Source: DNALC.DNAi

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15717. Mario Capecchi at work

Mario Capecchi at work in his laboratory.

  • ID: 15717
  • Source: DNAi

15701. Mouse

image of a mouse.

  • ID: 15701
  • Source: DNAi

15063. The advantages of mouse models for human disease, Mario Capecchi

Mario Capecchi talks about the advantages of working with mice to study genetic disorders.

  • ID: 15063
  • Source: DNAi

16857. Gallery 41: Mario Capecchi

Mario Capecchi, Distinguished Professor, Eccles Institute of Human Genetics.

  • ID: 16857
  • Source: DNAFTB

1712. Mouse (Mus musculus)

Mice are small, easy to keep, and complete a generation in only ten weeks. They are also rather closely related to human beings.

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  • Source: G2C

548. Model Center

Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.

  • ID: 548
  • Source: G2C

1715. Human (Homo sapiens) Cell Cutures

When model organisms cannot provide the information needed to answer a particular research question, biologists can turn to cultured human cells.

  • ID: 1715
  • Source: G2C

2009. Model animals (NOT animal models)

Doctor Thomas Insel makes the case for model animals with the power to see how candidate genes for human disorders could affect other systems.

  • ID: 2009
  • Source: G2C

15059. Gene targeting, Mario Capecchi

Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.

  • ID: 15059
  • Source: DNAi

16856. Animation 41: DNA is only the beginning for understanding the human genome.

Mario Capecchi describes proteomics; the large-scale study of protein structure and function. Brian Sauer explains gene knock outs.

  • ID: 16856
  • Source: DNALC.DNAFTB