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ID 15904

Neurofibromatosis 2

Description:
The NF2 gene produces a protein, called merlin, in the schwann cells that wrap around the axons of nerve cells. Merlin is a tumor suppressor protein, involved in regulation of the cell's activities. If the merlin protein is mutated, the schwann cells can change shape and reproduce at an unusual rate. This uncontrolled growth can lead to tumors around nerves in the ear and central nervous system.
Keywords:
nerve cells,schwann cells,nf2 gene,tumor suppressor protein,central nervous system,uncontrolled growth,axons,nerves,tumors
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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15962. What causes neurofibromatosis 2?
The NF2 gene produces a protein, called merlin, in the schwann cells that wrap around the axons of nerve cells. Merlin is a tumor suppressor protein, involved in regulation of the cell's activities. If the merlin protein is mutated, the schwann cells can
15961. What is neurofibromatosis 2?
The NF2 gene produces a protein, called merlin, in the schwann cells that wrap around the axons of nerve cells.
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