In the 1990s, DNA arrays provided the means to analyze patterns of gene expression at different timepoints in a living cell. DNA microarrays often consist of glass slides with spots of attached DNA fragments. The DNA fragments act as probes for specific sequences in a sample.
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Igor Dawid and Thomas Sargent explain how they developed subtractive mRNA hybrization to find genes expressed by different cell types. Pat Brown and Steve Fodor show how genomes can be screened with DNA arrays and GeneChipsï¿½