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ID 15926

Synthetic insulin

Making synthetic insulin is not as easy as it sounds. See what some of the challenges are.
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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15643. Genentech
Genentech, the first biotechnology company, established in 1976.
1877. IRS1/A0484
The insulin receptor substrate 1 (IRS1, also known as A0484) is a docking and adaptor protein that is multiply phosphorylated by a variety of protein kinases and is the major substrate of the insulin and insulin-like growth factor receptors (IGFRs).
15642. Insulin, pig, cow
The A and B chains of insulin. Insulin can be isolated from the pancreas of pigs and cows for human use.
15641. Charles Best and Frederick Banting
Charles Best (L) and Frederick Banting (R) discovered insulin, 1928.
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Walter Gilbert talks about the reasons for making insulin with recombinant DNA.
2207. Blood-brain barrier
Professor Bruce McEwen describes the blood-brain barrier, which prevents most proteins from accessing the brain. Selective proteins can cross the barrier, instigating processes such as neurogenesis.
1808. PDK1/A0260
The 3-phosphoinositide-dependent protein kinase 1 (PDK1 or A0260) is a serine/threonine protein kinase of the AGC group, PKB family.
15503. Tour of Genentech, David Ebersman
Tour of Genentech by David Ebersman
15927. Isolating DNA to make human insulin
Walter Gilbert's group tried to isolate the human insulin DNA sequence using the rat insulin DNA sequence.
15256. Producing rat insulin using recombinant DNA, Walter Gilbert
Walter Gilbert talks about his group's early success with isolating the rat insulin gene and making recombinant rat insulin.
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