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ID 2028

Senile plaques and Alzheimer's disease

Description:
Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.
Transcript:
As many people now are aware, the classical stigmata of Alzheimer’s disease, the classical hallmarks, are plaques and tangles. The senile plaque is an extracellular collection of protein. It’s a protein that is referred to as the a-beta. It’s a fragment of a normal protein we all have called the amyloid precursor protein. It gets chopped into a smaller piece called a-beta that then collects, assembles outside of cells, and forms this aggregate mass that forms a ball between the neurons, between the interstices of the brain, and pushes aside all of the fine ramifications and connections of brain cells to form what we call a plaque.
Keywords:
senile, plaques, amyloid precursor protein, abeta, interstice, kenneth, kosik
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Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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