Website Search
ID 2336

Neurofibrillary Tangles - Hallmark of Alzheimer's Disease

Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.
Neurofibrillary tangles are the other classic histopathological hallmark of Alzheimer’s disease. [They] are an intracellular lesion based on aberrant phosphorylation of the Tau protein that lead to sort of an accumulation of Tau, known as a tangle, inside the cell, ultimately leading to death of those neurons.
neurofibrillary, tangle, tau, protein, hallmark, alzheimer, brian, bacskai
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

2029. Neurofibrillary tangles and Alzheimer's disease
Professor Kenneth Kosik discusses neurofibrillary tangles, which form inside a cell and are made up of a protein called tau. There is a strong relationship with plaques and amyloid deposition.
1452. Tau Gene (MAPT)
Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.
2174. Neuron loss
Professor Donna Wilcock describes how neurofibrillary tangles choke neurons, causing them to die. This is one of three hallmarks of Alzheimer's disease.
2030. Tau protein and Alzheimer's disease
Professor Kenneth Kosik discusses the tau protein and its relationship to the neurofibrillary tangles found in Alzheimer's disease.
2173. Neurofibrillary tangles
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
2337. Optical Imaging of Plaque Formation
Doctor Brian Bacskai discusses how his group uses optical image to record plaque formation in Alzheimer's-type mice.
2227. Alzheimer's disease
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
1447. Alzheimer's Disease Candidate Genes
Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.
2335. Amyloid Plaques - Hall mark of Alzheimer's Disease
Doctor Brian Bacskai discusses how Amyloid plaques lead to a definitive diagnosis of alzheimer's disease.
2180. Immunotherapy fights Alzheimer's disease
Professor Donna Wilcock discusses an exciting finding from her research group that uses immunotherapy to prevent neurofibrillary tangles in mice.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving