Regulator of G-Protein Signaling 4 (RGS4) is a candidate gene for schizophrenia.
Transcript:
Regulator of G-Protein Signaling 4 (RGS4) negatively regulates signaling through G-proteins, so named because they bind the guanine nucleotides GDP and GTP. G-protein signaling activates “second messengers,” such as cyclic AMP, which in turn regulate many intracellular processes. RGS4 is involved in neuronal differentiation and is abundant in the cerebral cortex. RGS4 expression is reduced in brain tissue from schizophrenic patients, but no functional mutations have been identified.
Doctor Josh Dubnau explains that the cyclic AMP (cAMP) signaling network can receive signals from outside the cell and use the signal to alter the function of the cell.
The cyclic adenosine monophosphate (cAMP)-dependent protein kinase regulatory subunit 2 beta (PRKAR2B, also known as A0306) is one of the regulatory subunits of protein kinase A (PKA).
Professor David Lewis outlines how microarrays have transformed the search for schizophrenia genes and led to his group's discovery of the candidate gene, RGS4.
AKAP9 (A-kinase anchor protein), also known as yotiao or A0009, forms a macromolecular complex with different ion channels and recruits key enzymes such as cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) and protein phosphatase 1
Guanine nucleotide binding protein, beta 4 (GNB4), also known as A0072, is a member of the heterotrimeric guanine nucleotide-binding proteins (G proteins), which act as a modulator or transducer in various transmembrane signaling systems and relay ...