Website Search
ID 511
RGS4 Gene
Description:
Regulator of G-Protein Signaling 4 (RGS4) is a candidate gene for schizophrenia.
Transcript:
Regulator of G-Protein Signaling 4 (RGS4) negatively regulates signaling through G-proteins, so named because they bind the guanine nucleotides GDP and GTP. G-protein signaling activates “second messengers,” such as cyclic AMP, which in turn regulate many intracellular processes. RGS4 is involved in neuronal differentiation and is abundant in the cerebral cortex. RGS4 expression is reduced in brain tissue from schizophrenic patients, but no functional mutations have been identified.
Keywords:
schizophrenia, candidate, gene, RGS4, rgs, regulator, G-Protein, signaling, neuronal differentiation, cyclic amp, c-amp, camp, guanine, gtp, nucleotide, gdp
This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.Related content:
- 868. Candidate Genes for Schizophrenia
- An interactive chromosome map of the genes and loci associated with schizophrenia.
- SOURCE: G2C
- 510. GRM3 Gene
- Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
- SOURCE: G2C
- 1431. CAMP Signaling Network
- Doctor Josh Dubnau explains that the cyclic AMP (cAMP) signaling network can receive signals from outside the cell and use the signal to alter the function of the cell.
- SOURCE: G2C
- 1809. PRKAR2B/A0306
- The cyclic adenosine monophosphate (cAMP)-dependent protein kinase regulatory subunit 2 beta (PRKAR2B, also known as A0306) is one of the regulatory subunits of protein kinase A (PKA).
- SOURCE: G2C
- 1262. Microarray Studies of Schizophrenia
- Professor David Lewis outlines how microarrays have transformed the search for schizophrenia genes and led to his group's discovery of the candidate gene, RGS4.
- SOURCE: G2C
- 1828. AKAP9/A0009
- AKAP9 (A-kinase anchor protein), also known as yotiao or A0009, forms a macromolecular complex with different ion channels and recruits key enzymes such as cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) and protein phosphatase 1
- SOURCE: G2C
- 509. PPP1R1B Gene
- Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.
- SOURCE: G2C
- 1780. GNB4/A0072
- Guanine nucleotide binding protein, beta 4 (GNB4), also known as A0072, is a member of the heterotrimeric guanine nucleotide-binding proteins (G proteins), which act as a modulator or transducer in various transmembrane signaling systems and relay ...
- SOURCE: G2C
- 1778. GNB1/A0069
- Beta-1 subunit of guanine nucleotide binding protein (GNB1) is a member of a family of G protein beta subunit proteins, also known as A0069.
- SOURCE: G2C
- 1365. CREB1 Gene
- The cAMP response element-binding protein 1 (CREB1) gene is a CREB activator and has been found to facilitate long-term memory formation.
- SOURCE: G2C
