Website Search
ID 554

Single Nucleotide Polymorphisms

Description:
A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence.
Transcript:
The genetics of cognitive disorders is complex because diseases like schizophrenia or autism are associated with multiple genes. The genomic code is a long sequence written in only four letters – A,G,T, and C, which correspond to Adenine, Guanine, Thymine, and Cytosine. A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence. For instance, one individual may have a ‘G’ at this position, and another individual may have a ‘C.’ Changes in the DNA sequence can lead to changes in a gene’s biological function. For example, a change in the DNA sequence can lead to a change in the sequence of the protein that is produced, or it may cause a protein to terminate prematurely.
Keywords:
snp, snps, single nucleotide polymorphism, dna, sequence, polymorphism, nucleotide, schizophrenia, autism, genetics, diseases
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15242. Using RFLPs or SNPs to study patterns in families, Mark Skolnick
Mark Skolnick talks about using RFLPs or SNPs to study patterns in families
15557. Single nucleotide polymorphisms (SNPs)
An image of a family tree depicting the occurance of single nucleotide polymorphisms.
16884. Genome Scans Pay Off
Scans of the entire human genome turn up genes involved in common diseases.
15092. Studying the Y chromosome to understand population origins and migration, Michael Hammer
Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
553. Whole Genome Association
Special techniques are used for screening each individual’s genome for millions of different SNPs. This kind of comparison is referred to as a genome-wide association study.
15418. Mitochondrial DNA, Matt Ridley
Matt Ridley talks about Mitochondrial DNA.
1821. YWHAZ/A0361
YWHAZ, also known as A0361, encodes the zeta isoform of a family of proteins termed 14-3-3 proteins.
2309. Genotyping with Microarray Technologies
Doctor Anil Malhotra discusses new technologies that allow scientists to genotype large numbers of genetic polymorphisms.
1855. GAPDH/A0331
GAPDH (glyceraldehyde-3-phosphate dehydrogenase), also known as A0331, is an enzyme that catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate (GAP) in the presence of inorganic phosphate and nicotinamide adenine dinucleotide ..
793. Whole Genome Association
Jonathan Sebat, a researcher at Cold Spring Harbor Laboratory, discusses how association studies are used to determine the causes of genetic disorders.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving