Website Search
ID 912

EN2 Gene

Engrailed 2 (EN2) is a gene associated with autism.
EN2 (Engrailed 2) is a homeobox gene that is critical to the development of the midbrain and cerebellum. Like other homeobox genes, it regulates morphogenesis – the combined processes of cell division, differentiation, and organ development. EN2 is a human homolog of the engrailed gene, which is found in Drosophila. En2 mouse mutants have anatomic phenotypes in the cerebellum that resemble cerebellar abnormalities reported in autistic individuals. Four candidate gene studies have explored the relationship between EN2 and autism – three found a positive association.
EN2, engrailed, homeobox, gene, autistic, autism, cerebellum, midbrain, morphogenesis,
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

908. Autism Candidate Genes
Use this chromosome map to explore genes associated with autism.
920. MET Gene
The MET gene is important to brain development, particularly in the neocortex and cerebellum.
1975. Autism
An overview of autism-related content on Genes to Cognition Online.
471. Chromosome Map of Disorders and Processes
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
872. Autism Neuropathology
Autism is not associated with any single deficit in the brain.
880. Relatives' Brains and Autism
Brain scans of close relatives of children with autism reveal clear abnormalities that parallel those seen in autism.
919. SHANK3 Gene
The SHANK3 gene is associated with a number of cognitive disorders including autism.
1092. Multiple Genes for Autism
Professor David Skuse explains that it is highly probable that many different genes cause autism, with each gene contributing a small part to the symptomatology.
2386. Oxytocin And Autism
Doctor Larry Young discusses evidence of a relationship between oxytocin and autism, speculating that oxytocin may be used to treat autism.
883. Treating Autism
Exploring the possiblities of 'bringing back' the brain of a child with autism.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving