Professor Nelson explains that GSTP1 doesn't seem to be a gene in prostate cancer at least that's controlling growth, invasion, or metastasis.
Transcript:
William Nelson, M.D., Ph.D. is a researcher at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. HIs research focuses on the molecular causes involved in the development of prostate cancer. This has led to the discoveries that inflammation, diet, and gene "silencing" have roles in prostate cancer development.
“GSTP1 doesn't seem to be a gene in prostate cancer at least that's controlling growth, invasion, or metastasis or something that you might imagine a classical tumor suppressor gene to do. Rather, it seems to be a gene that controls the vulnerability to further gene damage by reactive oxygen species and carcinogens. So in that sense it acts more like a repair enzyme that is protecting the genome against damage.”
Keywords:
sidney kimmel comprehensive cancer center, sidney kimmel comprehensive cancer center at johns hopkins, tumor suppressor gene, gene damage, oxygen species, cancer development, professor nelson, sidney kimmel comprehensive, william nelson, prostate cancer, inflammation diet, metastasis, vulnerability, invasion
Professor Nelson explains that the prostate is actually a male sex accessory gland that contributes about a third of the secretions to the ejaculate for sexual reproduction.
Professor Nelson explains that chlorophyll is a remarkable energy scavenger and that there is some hint that if you consume chlorophyll you can intercept chemical species, that damage proteins, DNA, and RNA.
In order to identify cancer causes and prevention strategies, researchers conduct a cohort of studies where they collect information from large groups of individuals over many years.
Professor Nelson explains that there's something about diets of people who get prostate cancer that are a little different from the diets of people that don't.
In addition to enzymes produced by the body, certain components in food can also react with damaging chemicals, and an increased consumption of these foods may lower a person’s risk of cancer development.
Professor Angelo De Marzo explains that special dyes are utilized to stain cells and when we look at the stained cells under the microscope we look for changes in the architecture of cells.
Professor Angelo De Marzo explains that if you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly.