Genes to Cognition (G2C) Online

In 2005, we began development of Genes to Cognition (G2C) Online, a site on current research on the molecular basis of human thinking and disorders of thinking. The project is revolutionary because it was built in parallel with a major international research program—its namesake G2C at the Wellcome Trust Sanger Institute—and because it employs a nonlinear, network structure designed to provide a user-driven learning experience.

Genes to Cognition (G2C) Online examines thinking and disorders of thinking across six levels of analysis: Genes, Biochemicals, Cells, Brain, Cognition (Behavior), and Environment. If site visitors are interested in autism, they will be able to view the disorder through a number of lenses that represent a continuum of approaches to science. So, autism is seen not only as a disorder of behavior, but a disorder of the brain, of neural circuits that make up the brain, of cells that make up these circuits, of proteins that signal within these cells, and, finally, of genes that encode these proteins.

We have incorporated two ways of exploring the site: users can interact with the dynamic networks maps to explore more than 750 items of unique content, or choose to follow the Selected Items 'Subway Line' for a tour of highlighted content. G2C Online features a variety of content: 2- and 3-D animations, demonstrations, interactive maps, text articles, and video interviews. Interactive tools, including the G2C 3-D Brain, Fly School, Model Center, and Chromosome Map of Disorders and Processes, engage visitors. History, search, and glossary features assist with exploration.

G2C Online was produced by the DNA Learning Center of Cold Spring Harbor Laboratory. The project was supported by the Dana Foundation and the William and Flora Hewlett Foundation.

Simple Mapper

G2C Online's unique site architecture extends networking software developed at MIT's Media Lab, which displays content as an interlinked network of dimensional content "atoms." We redeveloped our browser software as Simple Mapper, to allow users to build their own network maps and then link atoms to online content from G2C or other sources. In addition to creating striking network maps, Simple Mapper can also be used to generate concept maps or workflows. Maps can be saved to a personal profile or shared with other users. User Groups can be created to facilitate sharing. Maps can also be made public and copied to your personal profile.

Cold Spring Harbor Laboratory
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