Website Search
ID 15415

Chromosome 20: gene for adenosine deaminase, Matt Ridley

Description:
Interviewee: Matt Ridley. Mutations in the sequence of the ADA gene (and another gene on the X chromosome called IL2RG) can cause severe combined immunodeficiency (SCID). People with SCID are prone to bacterial, viral, and fungal infections. (DNAi Location: Genome > Tour > Genome spots > Chromosome 20: Severe Combined Immunodeficiency (SCID) > A Chromosome story)
Transcript:
On chromosome 20 there's a gene for adenosine deaminase. In people in which this gene's not working, the immune system doesn't function properly, and they're vulnerable to infections. Now, some people have been partially cured of this, by gene therapy. That is, replacing the gene with a functioning copy, using a virus – an infectious virus – as a vector. Gene therapy holds a lot of promise, perhaps, but it's proved very difficult in practice to use as a weapon against disease.
Keywords:
adenosine deaminase,severe combined immunodeficiency,matt ridley,ada gene,x chromosome,infectious virus,dnai,gene name,fungal infections,interviewee,gene therapy,system doesn,mutations,immune system,vector,scid
Downloads:
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15966. What is Severe Combined Immunodeficiency (SCID)?
Mutations in the sequence of the ADA gene (and another gene on the X chromosome called IL2RG) can cause severe combined immunodeficiency (SCID). People with SCID are prone to bacterial, viral, and fungal infections.
15401. Chromosome 6: HLA genes and the human immune system, Matt Ridley
Matt Ridley talks about chromosome 6, HLA genes and the human immune system.
15405. Chromosome 10: gene which creates cortisol, Matt Ridley
Matt Ridley talks about chromosome 10, gene which creates cortisol.
15399. Chromosome 4: Huntington's Disease, Matt Ridley
Matt Ridley talks about chromosome 4, Huntington's Disease.
15408. Chromosome 13: BRCA2 gene for breast cancer susceptibility, Matt Ridley
Matt Ridley talks about chromosome 13, BRCA2 gene for breast cancer susceptibility.
15413. Chromosome 18: BCL2 oncogene, Matt Ridley
Matt Ridley talks about chromosome 18, BCL2 oncogene.
15414. Chromosome 19: APOE gene and susceptibility to Alzheimer's, Matt Ridley
Matt Ridley talks about chromosome 19, APOE gene and susceptibility to Alzheimer's.
15406. Chromosome 11: gene for dopamine receptors, Matt Ridley
Matt Ridley talks about chromosome 11, gene for dopamine receptors.
15398. Chromosome 3: gene associated with alkaptonuria, Matt Ridley
Matt Ridley talks about chromosome 3, gene associated with alkaptonuria.
15410. Chromosome 15: Prader-Willi's disease, or Angelman's syndrome, Matt Ridley
Matt Ridley talks about chromosome 15, Prader-Willi's disease, or Angelman's syndrome
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving