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ID 1215

PSD-95 Mutations

Description:
In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
Transcript:
PSD95 is a protein that binds to the inside surface of neurotransmitter receptors, and when we mutated that protein in mice, we found that the animals had impaired learning, but the receptor still acted normally. This established that neurotransmitter receptors act through the proteins associated with them to lay down the memory trace. It’s not just about the receptor, it’s about the proteins associated with it.
Keywords:
psd95, psd-95, psd, 95, post-synaptic, postsynaptic, density, neurotransmitter, receptor, protein, gene, molecule, learning, memory, seth, grant
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Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
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Post-synaptic density 95 protein (PSD95), also known as synapse-associated protein 90 (SAP90) or A0013, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
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Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.
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Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
1834. SAP102/A0016
Synapse-associated protein 102 (SAP102 or A0016) is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
1829. PSD93/A0014
Post-synaptic density protein 93 (PSD93), also known as channel-associated protein of synapse-110 (Chapsyn-110) or A0014, is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD93, PSD95, SAP97, SAP102).
1764. SHANK2/A0081
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1216. Hebbosome
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897. Gene knockout in mice
This method uses homologous recombination to disable a gene of interest to produce a genetic knockout.
1390. Genes for Learning and Memory
An interactive chromosome map of the genes and loci associated with learning and memory.
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