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ID 1368

DLG4 Gene

Description:
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
Transcript:
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse Psd95 proteins. Migaud and colleagues (1998) examined mice that lack this protein and found evidence of severe impairments in spatial learning. This was reflected by irregularities in long-term potentiation in the brain. These changes may be caused by a disruption of the NMDA receptor, which can bind PSD-95, at the synapse. In the absence of PSD-95, the NMDA receptor synaptic complex may become uncoupled from pathways that control plasticity and learning.
Keywords:
Discs, large homolog 4, DLG4, learning, memory, psd95, gene, protein, nmda, synapse, disruption, plasticity
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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