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ID 938

Hallmarks, Overview: Hanahan

Description:
Professor Douglas Hanahan discusses how cancer acquires capabilities and these capabilities are all, to some approximation, necessary to produce a successful tumor.
Transcript:
In 2000, Douglas Hanahan (shown below) and Robert Weinberg published a paper in Cell, "The Hallmarks of Cancer," which identified some organizing principles of cancer cell development. “We believe that cancer acquires capabilities and that these capabilities are all, to some approximation, necessary to produce a successful tumor. And these may not be a complete description of a tumor but they, probably just in the same way as you describe a car as having a motor and some wheels and tires and a gas tank and some brakes you haven't completely described the car, but you've described a lot of the capabilities that allow it to do what it does. So I think the same issue here is that tumors have a set, a minimal set, of capabilities, that we think are necessary, and so we call these the hallmarks of cancer.”
Keywords:
robert weinberg, wheels and tires, cancer cell, professor douglas, hallmarks, tumor, tumors
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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