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Hallmarks, Invading tissues: Hanahan

Description:
Professor Douglas Hanahan discusses how cancers kill you, in general, not just because they grow into a large lump, but because they invade into normal tissues and disrupt the functions of those tissues.
Transcript:
In 2000, Douglas Hanahan (shown below) and Robert Weinberg published a paper in Cell, "The Hallmarks of Cancer," which identified some organizing principles of cancer cell development. “Cancers kill you, in general, not just because they grow into a large lump, but because they invade into normal tissues and disrupt the functions of those tissues and they develop the ability to migrate to distant sites in the body. And these capabilities of invasion and metastasis, which are very closely linked but perhaps have separable aspects as well, are very important for the fatality of most cancers. And this is the one that's perhaps least connected to simple cell growth and accumulation of the cells, but actually are producing cells that really are able to sustain themselves, expand, and migrate.”
Keywords:
invasion and metastasis, robert weinberg, cancer cell, professor douglas, hallmarks, fatality, cancers, accumulation, tissues, cells, capabilities
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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