Interviewee: Frederick Sanger.
Frederick Sanger talks about the results from sequencing human mitochondrial DNA.
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Sequencing mitochondrial DNA)
And one interesting thing we found was that the genetic code was different in the mitochondria from what it was in the rest of the human body, which was quite important. And of course, the actual sequence of the, we got the sequence of the DNA and from that you can work out the sequence of the few proteins that are made. And the sequence of those proteins varies considerably from individual, one individual to another, so one outcome was a method for tracing people's ancestry and, in criminal problems, you can identify differences in DNA of people.
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Two sequencing techniques were developed independently in the 1970s. The method developed by Fred Sanger used chemically altered "dideoxy" bases to terminate newly synthesized DNA fragments at specific bases (either A, C, T, or G). These fragments are th