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ID 15927

Isolating DNA to make human insulin

Description:
Walter Gilbert's group tried to isolate the human insulin DNA sequence using the rat insulin DNA sequence.
Keywords:
isolating dna,rat insulin,human insulin,dna sequence,walter gilbert,gilbert walter
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15256. Producing rat insulin using recombinant DNA, Walter Gilbert
Walter Gilbert talks about his group's early success with isolating the rat insulin gene and making recombinant rat insulin.
16117. Close but no cigar, Walter Gilbert
Walter Gilbert talks about close but no cigar.
15259. Cloning the human insulin gene, Walter Gilbert
The recombinant DNA moratorium meant Gilbert had to go to England's Porton Down facility to try and isolate human insulin. He only had one chance ...
15088. Gilbert's approach to synthesizing insulin, David Goeddel
David Goeddel talks about how another group was trying to make insulin.
15255. Producing human insulin using recombinant DNA, Walter Gilbert
Walter Gilbert talks about the reasons for making insulin with recombinant DNA.
15258. Government restrictions on working with recombinant DNA, Walter Gilbert
In the late 1970s, there was a moratorium on recombinant DNA work. Gilbert had to go to England's Porton Down facility to try and isolate human insulin.
15257. Trying to produce insulin using recombinant DNA, Walter Gilbert
Walter Gilbert talks about his feelings regarding the insulin project and science in general.
16698. Video 33: Walter Gilbert, clip 5
Jacob and Monod never identified the inhibitor, but Gilbert found it.
16697. Video 33: Walter Gilbert, clip 4
How Jacob and Monod showed the existence of the inhibitor (what Gilbert calls the repressor).
16694. Video 33: Walter Gilbert, clip 1
Before Jacob and Monod, people thought the amount of protein in a cell was constant and proteins turned themselves off.
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